Which syndrome is associated with a chromosomal anomaly affecting males more severely?

Fragile X syndrome is associated with a specific chromosomal anomaly, specifically a mutation on the FMR1 gene located on the X chromosome. This genetic condition has a significant impact on males, typically manifesting more severely than in females due to the way X-linked inheritance operates. Males have only one X chromosome, so if that chromosome carries the mutation, they will express the syndrome. In contrast, females have two X chromosomes, which means that if one X chromosome has the mutation, the other X can potentially compensate, often resulting in milder symptoms.

Individuals with Fragile X syndrome may present with intellectual disabilities, behavioral challenges, and physical characteristics, among other symptoms. This condition emphasizes the importance of understanding genetic factors in special education, particularly how they can differentially affect students based on their gender.

The other choices do not relate to this specific context. Down syndrome is a result of an extra chromosome 21 but does not exhibit the same gender-related severity. Amniocentesis is a prenatal diagnostic procedure and does not pertain to a syndrome itself. Normalization refers to a principle in special education focused on integrating individuals into society but is not a syndrome associated with chromosomal anomalies.